about eight years ago to live with news that we gradually come to future medical treatments related to the use of stem cells due to the potential of these cells in the regeneration of various tissues . Adult stem cells from the patient that can autograft for example, in the heart to try to regenerate an area affected, as has been done in some hospitals or even the possible use of pluripotent embryonic cells, whose experiments in mice have shown some potential. However use of human embryonic stem cells entails difficult ethical issues.
This week has been published in the journal Nature, two papers of great importance related to the possible derivation of pluripotent cells, like embryonic stem cells would avoid these issues. First, two separate groups of researchers in the U.S. Jaenisch and Yamanaka in Japan, have managed to get "cells induced pluripotent "from somatic cells of the skin of mice. To do this, introduced by retroviral vectors in somatic cells, four genes for transcription factors known to somehow "wake up" dormant cells of conferring properties similar to embryonic stem cells. The most obvious difficulty of these experiments is that viral particles are used, and transcription factors that can develop cancer and therefore could not be used in patients, so after playing these experiments with human cells, which are probably needed more than four factors should be find a way compatible with a possible rescheduling implant humanos.El another article that I referred to is Kevin Eggan of Harvard University. In this research, instead of using adult cells embryonic cells used mouse aberrant, ie an abnormal chromosome. I must say that in assisted reproduction occur 3-5% of zygotes with abnormal chromosome, for example by being fertilized egg by two sperm at the same time. These zygotes are not viable at all and are therefore discarded. The above experiments suggest that these non-viable zygotes could be stripped of replacing it with the genetic material of the patient. The "induced pluripotent cells" derived from this other way may also be useful without giving rise to ethical issues that currently overshadow the experiments with embryonic cells humanas.Las two possibilities, both the reprogramming of somatic cell nuclear transfer as a possible to aberrant zygotes, are still many issues to resolve, the only answer is to continue investigating.
This week has been published in the journal Nature, two papers of great importance related to the possible derivation of pluripotent cells, like embryonic stem cells would avoid these issues. First, two separate groups of researchers in the U.S. Jaenisch and Yamanaka in Japan, have managed to get "cells induced pluripotent "from somatic cells of the skin of mice. To do this, introduced by retroviral vectors in somatic cells, four genes for transcription factors known to somehow "wake up" dormant cells of conferring properties similar to embryonic stem cells. The most obvious difficulty of these experiments is that viral particles are used, and transcription factors that can develop cancer and therefore could not be used in patients, so after playing these experiments with human cells, which are probably needed more than four factors should be find a way compatible with a possible rescheduling implant humanos.El another article that I referred to is Kevin Eggan of Harvard University. In this research, instead of using adult cells embryonic cells used mouse aberrant, ie an abnormal chromosome. I must say that in assisted reproduction occur 3-5% of zygotes with abnormal chromosome, for example by being fertilized egg by two sperm at the same time. These zygotes are not viable at all and are therefore discarded. The above experiments suggest that these non-viable zygotes could be stripped of replacing it with the genetic material of the patient. The "induced pluripotent cells" derived from this other way may also be useful without giving rise to ethical issues that currently overshadow the experiments with embryonic cells humanas.Las two possibilities, both the reprogramming of somatic cell nuclear transfer as a possible to aberrant zygotes, are still many issues to resolve, the only answer is to continue investigating.
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