Some studies in laboratory animals support the hypothesis that a reduction in nutrient intake increases longevity . Recently in the journal "Nature" was published the existence of parallel molecular mechanisms that could explain the involvement of different genes in this pathway. This discovery could allow in the future, improve health and extend the average life of the people.The we mentioned a few months ago in this very "blog" (08/03/2007) longevity is reached, no doubt, habits lifestyles, but also influenced by a certain "genetic load." The journal Nature (vol. 447) has recently published two articles (pages 545 and 550) that two new genes PHA4 and SKN-1 are directly related to the observed longevity in worms (Caenorhabditis elegans ), such as those are shown in the photo, which reduces their nutritional intake bacteriana.La nutrient depletion in mammals, specifically carbohydrates, is associated with decreased activation of the signals characteristic of insulin, a hormone our pancreas releases in response to plasma glucose levels, in fact many weight loss diets "decoupled" is based on carbohydrates do not mix with other nutrients such as protein or fat, to avoid this increase in insulin. The reduction of the signals characteristic of this hormone as well as other parallel mechanisms involving PHA4 and SKN-1, appear to originate, among other things, the activation of genes that increase our defenses against free radicals that will inevitably occur in cells that are a cause of aging. Studies of the mechanisms involving these genes in longevity and its parallels in mammals will be of great interest in the next años.Nuestra intake is associated with appetite. There are substances that our body produces to allow the brain to know if we need or do not eat, such as leptin produced by our adipose tissue and informs the brain that we have eaten enough and that it is better to spend the accumulated energy. Humans do not respond to leptin develop obesity. Apply this knowledge in human beings still require many studies but meanwhile we now know that probably remain a little hungry after a meal may help us live a little longer.
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